消化性潰瘍臨床病理特徵及其與幽門螺桿菌感染的關係

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摘要

目的

探討消化性潰瘍臨床病理特徵及其與幽門螺桿菌（Hp）感染的關係。

方法

回顧性分析2013年6月至2016年6月在中日友好醫院行電子胃鏡確診的230例消化性潰瘍患者的臨床資料。經過Hp感染檢驗，根據患者是否Hp感染，分為Hp（-）組和Hp（+）組。電子胃鏡觀察消化性潰瘍的臨床病理特徵，分析消化性潰瘍的臨床病理特徵及其與Hp感染的關係。

結果

Hp感染檢查結果顯示，Hp（-）組 55例和Hp（+）組 175例。Hp（+）組服用非甾體消炎藥比例低於、而上腹疼痛比例高於Hp（-）組（均PP＜0.05）。

結論

潰瘍病變類型以十二指腸潰瘍最多，胃潰瘍次之，消化性潰瘍臨床病理特徵改變與Hp感染密切相關。

Relation between clinicopathological features of peptic ulcer and helicobacter pylori infection

Objective

To investigate the relation between clinicopathological features of peptic ulcer and helicobacter pylori（Hp） infection.

Methods

Clinical data of 230 patients diagnosed of peptic ulcer by electronic gastroscopy from June 2013 to June 2016 in China-Japan Friendship Hospital were analyzed retrospectively. According to results of Hp infection test, the patients were divided into Hp(-) group and Hp(+) group. Clinical and pathological features of peptic ulcer were observed. The relationship between peptic ulcer and Hp infection was analyzed.

Results

There were 55 cases in Hp(-)group and 175 cases in Hp(+) group. The use ratio of non-steroidal anti-inflammatory drugs in Hp(+) group was significantly lower and the epigastric pain ratio was significantly higher than those in Hp(-) group(P＜0.05). Among 230 cases of peptic ulcer, 75 cases(32.6%) were gastric ulcer, 123 cases(53.5%) were duodenal ulcer and 32 cases(13.9%) were complex ulcer. Duodenal ulcer mainly located in anterior wall and greater curvature; gastric ulcer mainly located in gastric angle and antrum; complex ulcer mainly located in anterior wall and gastric antrum. The gastric ulcer ratio in Hp(+) group was significantly lower than that in Hp（-） group; ratios of duodenal ulcer, severe mucositis and active severe inflammation in Hp(+) group were significantly higher than those in Hp（-） group［25.7%（45/175） vs 54.5%(30/55), 62.9%（110/175） vs 23.6%(13/55), 45.7%（80/175） vs 27.3%(15/55), 57.1%（100/175） vs 27.3%(15/55)］（P＜0.05）.

Conclusion

Peptic ulcer mainly locates in duodenal and gastric mucosa; clinicopathological features of peptic ulcer are closely related to Hp infection.

轉自：中國醫藥雜誌

作者：秦耿 王慧芬 白如雪 王秀紅 杜時雨

來源：中國醫藥. 2017, 12(10):1549-1551

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