寨卡病毒動物感染模型的最新進展cGAS的調控機制

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REVIEW

寨卡病毒動物感染模型的最新進展

作者：董澍芃, 梁啟明

單位：

上海市免疫學研究所，免疫與微生物系，上海交通大學醫學院

摘要:寨卡病毒屬於由蚊子傳播的黃病毒，2015年在南美洲爆發，並由繼續擴展到北美洲以及全世界的趨勢。寨卡病毒在1947年首次被發現，直到2007年只有14個人類被感染的報告。該病毒感染以前只引起類似於流感的癥狀。但是近期的寨卡病毒感染被聯繫到小頭病等神經及發育性疾病。因此研究人員通過建立不同的動物感染模型來研究寨卡病毒的傳播和致病，以及對潛在治療療效的評價。此綜述主要討論寨卡病毒的動物感染模型。

Abstract:An infection by Zika virus (ZIKV), a mosquito-borne flavivirus, broke out in South American regions in 2015, and recently showed a tendency of spreading to North America and even worldwide. ZIKV was first detected in 1947 and only 14 human infection cases were reported until 2007. This virus was previously observed to cause only mild flu-like symptoms. However, recent ZIKV infections might be responsible for the increasing cases of neurological disorders such as GuillainBarre′ syndrome and congenital defects, including newborn microcephaly. Therefore, researchers have established several animal models to study ZIKV transmission and pathogenesis, and test therapeutic candidates. This review mainly summarizes the reported animal models of ZIKV infection, including mice and non-human primates.

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