什麼是研究人類對H7N9禽流感病毒易感性的試劑來源？

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禽流感H7N9病毒是一個重要的公共衛生問題，由於它的高死亡率和引發未來大流行的潛力。

研究人員使用重組H7N9血凝素蛋白作為探針，研究了人類對H7N9病毒的易感性。在2016年流行季節的中國江蘇省的32個病例的唾液標本和60例未感染的對照樣本中，研究人員發現在H7N9感染和血凝素結合之間一個強的相關性。研究人員也發現被H7N9病毒識別的唾液酸Lex(SLex)抗原也與該病毒感染有關。進一步分析表明，毗鄰SLex的額外的糖殘基可能影響H7N9病毒結合的特異性。

該實驗數據表明，唾液可能是研究人類對H7N9病毒易感性的有用的試劑，這會影響對這種重要的人類病原引起疾病的預防和控制。

圖1功能性H7型病毒HA1蛋白的產生和驗證

圖2唾液標本S60-HA1蛋白結合信號和H7N9感染之間的關聯

ABSTRACT

Avian influenza H7N9 viruses are an important public health concern due to their high mortality rate and potentials for future pandemics. We investigated human susceptibility to H7N9 viruses using recombinant H7N9 hemagglutinin (HA) proteins as a probe and found a strong association between H7N9 infections and HA binding among saliva samples from 32 patients and 60 uninfected controls in Jiangsu province, China, during the 2016 epidemic season. We also found that sialyl Lex (SLex) antigen that was recognized by H7N9 HA was associated with H7N9 virus infection. Further analysis suggested that additional saccharide residues adjacent to the SLex moiety may affect the H7N9-binding specificity. Our data suggested that saliva may be a useful reagent to study human susceptibility to avian influenza H7N9 virus, which may impact the disease control and prevention of avian influenza viruses as important human pathogens.

本期編輯：烏龜

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