抗乙型肝炎病毒HBV二萜的發現

結果速覽

近日，山西大學學者報道從一種蕘花屬植物的芽中分離得到了11個二萜化合物，其中包括7個新化合物，並報道了它們的抗病毒活性。相關研究發表於Phytochemistry，題為「Diterpenes from buds ofWikstroemia chamaedaphneshowing anti-hepatitis B virus activities」。

分得的化合物結構如下圖所示，其中化合物1-3、6-9為新化合物。

拉米夫定和替諾福韋作陽性對照，化合物的活性如下圖：

Abstract:Phytochemical study of the buds of Wikstroemia chamaedaphne Meisn. led to the isolation of seven previously undescribed diterpenes, including one tigliane diterpene (wikstchalide A), two daphnane dit erpenes (wikstroelides W-X), and four lathyrane diterpenes (laurifoliosides A-B and 2-epi-laurifoliosides A-B), along with four known diterpenes. The structures of these compounds were established by extensive spectroscopic evidence and electronic circular dichroism (ECD) calculations. Wikstchalide A possesses a 5,6-epoxy ring in the tigliane skeleton. Two compounds exhibited potential anti-hepati tis B virus activities, with IC50 values of 46.5 and 88.3 mg/mL against hepatitis B virus (HBV) surface antigen (HBsAg), and six compounds showed certain inhibitory effects on HBV-DNA replication with the inhibition ratios ranging from 2.0% to 33.0%at the concentrations ranging from 0.39 to 6.25 mg/mL

文章doi：10.1016/j.phytochem.2018.01.021

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