山東第一醫科大學史衛峰課題組發表關於lncRNA調控病毒-宿主相互作用的綜述文章

2019年4月23日，Reviews in Medical Virology在線發表了關於長鏈非編碼RNA（long non-coding RNAs, lncRNAs）與病毒複製相互調節的綜述文章（Long noncoding RNAs Novel regulators of virus‐host interactions），基礎醫學院青年教師劉紹瓊博士為第一作者，史衛峰教授和張振傑副教授為共同通訊作者。

作為一類新型的關鍵細胞調控因子，lncRNA以多種機制參與哺乳動物細胞生物功能調控。越來越多的證據表明，lncRNA在宿主與病原體相互作用過程中發揮重要作用。細胞內多種lncRNAs可被DNA、RNA病毒感染或細胞因子誘導表達。同樣，lncRNAs作為調控因子，可在包括病原識別受體（PRR）的信號轉導、表觀遺傳學、轉錄及轉錄後等多個水平，以不同機制抑制或激活天然免疫應答反饋於病毒感染。文章闡述了與病毒感染相關的lncRNA、細胞因子和代謝物質相互之間作用的新模式，重點歸納了它們在宿主抗病毒應答過程中所形成的調控網路，並強調了lncRNA生物學和免疫學交叉研究的新領域。

Summary

Long noncoding RNAs (lncRNAs) represent a key class of cellular regulators, involved in the modulation and control of multiple biological processes. Distinct classes of lncRNAs are now known to be induced by host cytokines following viral infections. Current evidence demonstrates that lncRNAs play essential roles at the host‐pathogen interface regulating viral infections by either innate immune responses at various levels including activation of pathogen recognition receptors or by epigenetic, transcriptional, and posttranscriptional effects. We review the newly described mechanisms underlying the interactions between lncRNAs, cytokines, and metabolites differentially expressed following viral infections; we highlight the regulatory networks of host antiviral responses and emphasize the need for interdisciplinary research between lncRNA biology and immunology to deepen understanding of viral pathogenesis.

本期編輯：Tony

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