孔祥田教授朋友圈日常病例分享（8）

最新 07-04

來源：孔祥田黃文斌（譯）

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病例1

Pigmented villonodular synovitis（PVNS）。 Wow. Knee arthroscopy image! H&E @WebPathology: papillary projections, giant cells, hemosiderin. #BSTpath

病例1 色素性絨毛結節性滑膜炎（PVNS）。喔，膝關節鏡圖像！HE@WebPathology: 乳頭狀突起，巨細胞，含鐵血黃素。#BSTpath

病例2

Lipoblast （in pleomorphic liposarcoma）： 1. Pleomorphic nucleus. 2. Clear & round vacuoles 3. often indent nucleus. #ASCP40underForty2017 - twitter

病例2 脂母細胞（多形性脂肪肉瘤內）：1. 多形性核。2. 透亮和圓形的空泡。3. 核常凹陷#ASCP40underForty2017 - twitter

病例3

Sebaceous glands in normal parotid #Entpath #pathology - twitter

病例3 正常腮腺內的皮脂腺#Entpath #pathology - twitter

病例4

Advanced invasive penoscrotal and perianal extramammary Paget s disease with prominent lymphovascular invasion & mets （not shown） #dermpath - twitter

病例4 進展性浸潤性陰莖陰囊和肛周乳腺外Paget病伴明顯的淋巴血管侵犯和轉移（未顯示） #dermpath - twitter

病例5

Meningothelial-like nodules of lung: cells within alveolar septa, very bland, very minute to mm sized

#tap4saat #pfotd #pulmpath - twitter

病例5 非的腦膜上皮樣結節：細胞位於肺泡隔內，非常溫和，病變非常小到數mm。#tap4saat #pfotd #pulmpath - twitter

Although pulmonary meningothelial-like nodules （MLNs） have been recognized for decades, their nature and significance remain uncertain. This study was undertaken to evaluate MLNs in a wide range of specimens to clarify their incidence, distribution, relation to age and underlying disease, and histogenesis. Five hundred surgical lung biopsies, 25 extensively sampled lobectomies, 20 resections for pneumothoraces in persons younger than 30 years, and 92 pediatric autopsies were examined. Immunohistochemistry was performed in selected cases. One hundred eighty-six MLNs were identified in 81 cases, including 69 of 500 （13.8%） surgical biopsies and 12 of 25 （48%） lobectomies. No MLNs were found in pneumothorax resections or pediatric autopsies. Patients ranged from 22 to 84 years （mean, 62）， with only 4 younger than 40 years. There were 56 women and 25 men （female:male=2.2:1）。

雖然肺腦膜上皮樣結節（MLNs）被認識多年，但它們的本質和意義還不清楚。本研究在較多樣本內進行MLNs的評估，用於闡明其發生率、分布、與年齡和其下疾病的關係以及組織發生。本項研究共收集了500例外科肺活檢標本、25例廣泛取材的肺葉切除標本，20例30歲以下因氣胸而性手術切除的標本以及92例兒童屍檢病例。部分病例進行了免疫組織化學檢測。結果在81例病例中發現了186個MLNs，包括69例外科活檢（13.8%,69/500）、12例肺葉切除標本（48%,12/25）。氣胸切除標本或兒童屍檢病例均未見到MLNs。病人年齡22-84歲（平均62歲），僅有4例發病年齡在40歲以下。女性56例，男性25例（女：男=2.2:1）。