韓春雨及同事發表於《自然-生物技術》論文最新聲明

關於韓春雨及同事發表於《自然-生物技術》的「DNA-guided genome editing using the Natronobacterium gregoryi Argonaute」（利用NgAgo進行DNA引導的基因組編輯）一文的聲明

Statement regarding「DNA-guided genome editing using the Natronobacterium gregoryi Argonaute」 by Han Chunyu and colleagues, published in Nature Biotechnology

《自然-生物技術》今天就此前發表的韓春雨及同事所著論文「利用NgAgo進行DNA引導的基因組編輯」發表了「編輯部關注」，並發表Toni Cathomen及同事的通信文章，題為「利用Natronobacterium gregoryi Argonaute（NgAgo）未能檢測到DNA引導的基因組編輯」。

Nature Biotechnology is today publishing an Editorial Expression of Concern, alongside a Correspondence entitled 「Failure to detect DNA-guided genome editing using Natronobacterium gregoryi Argonaute」 by Toni Cathomen and colleagues, in relation to a previously published paper 「DNA-guided genome editing using the Natronobacterium gregoryi Argonaute」 by Chunyu Han and colleagues.

Nature Biotechnology has carefully considered all comments relating to the original paper by Han and colleagues. As in all cases where apaper encounters criticisms after publication, we have undertaken a careful and thorough evaluation of these criticisms. Today, we are publishing not only a Correspondence by Cathomen and colleagues that may refute the main finding of efficient editing of an endogenous gene claimed in the original paper, but alsoan Editorial Expression of Concern alongside the original paper to ensure that readers are aware of the concerns raised by the paper by Cathomen and colleagues and a report published elsewhere in the literature(doi:10.1007/s13238-016-0343-9). At this time, two authors of the original paper, Chunyu Han and Xiao Shen, agree with this Editorial Expression of Concern, whereas Feng Gao, Feng Jiang and Yongqiang Wu do not feel that it is appropriate.

《自然-生物技術》認為，讓原作者在能力所及的情況下對上述通信文章所提出的擔憂展開調查，並補充信息和證據來給原論文提供依據是非常重要的。因此，我們將繼續與原論文的作者保持聯繫，並為他們提供機會，以在2017年1月底之前完成其調查。屆時，我們會向公眾公布最新進展。

Nature Biotechnology believes that it is important for authors to be able to investigate the concerns raised by the Correspondence and to provide additional information andevidence to support their paper if they are able to do so. Thus, we will continue to liaise with the authors of the original paper to provide them with the opportunity to do that by January 2017. An update will be provided to the community at that time.

編輯部關註：利用NgAgo進行DNA引導的基因組編輯

Editorial Expression of Concern: DNA-guided genome editing using the Natronobacterium gregoryi Argonaute

The editors of Nature Biotechnology are issuing an editorial expression of concern regarding this article to alert our readers to concerns regarding the reproducibility of the original results. At this time, we are publishing the results of three groups (http://dx.doi.org/10.1038/nbt.3753) that have tried to reproduce the results in the critical Figure 4 in the original paper by Han and colleagues, which demonstrates editing of endogenous genomic loci in mammalian cells. None of the groups observed any induction of mutations by NgAgo at any of the loci or underany of the conditions tested above the sensitivity of the assays used. Similar results have been recently reported by a different group of authors in Protein& Cell(doi:10.1007/s13238-016-0343-9).

我們和論文作者進行了溝通，他們正在調查造成可重複性缺乏的潛在原因。我們向其告知了這一聲明。儘管調查仍在進行中，但韓春雨和沈嘯同意我們的發布這一編輯部關注，高峰、姜峰和Yongqiang Wu則認為目前並不合適。這些調查一旦完成，我們會向讀者提供最新信息。

We are in contact with the authors, who are investigating potential causes for the lack of reproducibility. The authors have been informed of this statement. While the investigations are ongoing, Chunyu Han and Xiao Shen agree with this editorial expression of concern. Feng Gao, Feng Jiang and Yongqiang Wu do not feel that it is appropriate at this time. We will update our readers once these investigations are complete.

轉載自《Nature自然科研》

TAG:DeepTech深科技 |

※新華社：《自然·生物技術》仍在調查韓春雨論文爭議
※《自然生物技術》：擔憂韓春雨論文可重複性
※韓春雨論文 | 《自然·生物技術》最新回復
※周軍教授課題組在《自然·納米技術》發表論文
※申文江：質子技術國內外發展概況／《質子治療臨床現狀》之二
※三國際團隊重複韓春雨實驗失敗，《自然-生物技術》稱1月結束調查
※中國學者再次發表關於ＮｇＡｇｏ技術的論文
※韓春雨終於在《自然-生物技術》設定期限前提交了結果
※英國最新情報震動世界，中美竟掌握相同軍事技術
※藝術史：傳統日本文身的古代技術與演變
※物聯網的造反:秘魯古老文明預言我們的技術焦慮
※神秘的印加文明遺址奧揚泰坦博，現代人無法理解的遠古工程技術
※技術解讀電影：翻拍自香港《大事件》的《莫斯科大事件》中的武器
※最新研究：我們「極可能」並非宇宙中唯一先進技術文明！
※《我在故宮修文物》，是逆今為止唯一一部揭秘世界頂級文物「復活」技術！
※《自然-生物技術》否定韓春雨基因工作 明年1月完成調查
※將影視技術用於苗族優秀傳統文化傳承的思考
※黎勵文專訪：傳遞診療技術新理念 推動心衰一體化管理
※技術宅教你召喚《奇異博士》特效魔法陣